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Catalyzed by DNA methyltransferases (DNMT1, DNMT2, DNMT3a, DNMT3b), it involves the transfer of a methyl group from S-adenosylmethionine (SAM) to the 5 carbon position of cytosine residues, subsequently silencing gene expression by impeding transcription factor binding

doi: 10.1016/j.biopsych.2015.08.036 144 VargasDLNascimbeneCKrishnanCZimmermanAWPardoCA

Il sagit dun tripeptide, cest--dire dun complexe constitu de trois acides amins : la glutamine, la cystine et la glycine

If the shunt is significant, there is progressive damage to the pulmonary vasculature and gradual development of irreversible pulmonary hypertension